Anti-ulcer Activity of Excoecaria agallocha bark on NSAID-induced Gastric Ulcer in Albino Rats

The plant extract of Excoecaria agallocha bark herbal preparation that has been suggested as useful in the treatment of varies diseases (anti tumor, anti microbial, anti wound killing agents and anti oxidant). In this, study to determine the gastro protective effect of E. agallocha in a model of NSAID induced ulcer rat. The lyophilized extract was given by oral gavages (125 and 62.5mg/kg) three times at 12 h intervals before administering dicolofenac 100mg/kg. Pretreatment with the extract resulted in a significant decreased of the ulcerated area. The volume and acidity of the gastric juice decreased in the pretreated rats. The plant extract was elevated in the gastric juice of untreated rats, showed hear normal levels in the pretreated rats. The E. agallocha was able to decrease the acidity and increase the mucosal defense in the gastric areas, there by justifying its use as an antiulcerogenic agent.